BrainSleep Co., Ltd. (Headquarters: Chiyoda-ku, Tokyo; Representative Director: Atsushi Hirota; hereinafter "BrainSleep") will release two new products in its "BrainSleep Supplement GABA" (hereinafter "Supplement GABA") series of multi-functional sleep supplements. These are Foods with Function Claims that improve sleep quality while addressing health concerns with a single tablet. The new products are "BrainSleep Supplement GABA + Thermo" (hereinafter "Supplement GABA Thermo"), which specializes in improving circulation, and "BrainSleep Supplement GABA + Diet" (hereinafter "Supplement GABA Diet"), which specializes in weight loss. Both will be available on the BrainSleep Official Website from Wednesday, October 22nd. In addition to , which improves sleep quality and reduces stress and fatigue, and , which regulates gut health, these supplements now include to alleviate cold hands and feet and leg swelling, and to improve weight, body fat, neutral fat, and BMI. These additions enhance sleep quality, reduce stress, support gut care, and further aid in circulation improvement and weight loss. Development Background The "Supplement GABA" series focuses on the "brain-gut axis," the bidirectional communication between the brain and the gut. It's a supplement that simultaneously cares for sleep and the gut with , which improves sleep quality and reduces stress, and , which regulates gut health. In fact, it has been shown that good gut health improves sleep quality. *1 "Supplement GABA Thermo" addresses "cold sensitivity," a health concern that particularly affects sleep quality, especially as the seasons change. For good sleep onset, a change in body temperature occurs where the internal body temperature (core body temperature) decreases and the external body temperature (skin temperature) increases. However, people with cold sensitivity tend to have difficulty lowering their core body temperature and their skin temperature also tends not to rise due to poor peripheral blood circulation. "Supplement GABA Diet" focuses on the relationship between sleep and obesity. Multiple studies have shown that 3 out of 4 people who suffer from snoring or sleep apnea syndrome (SAS) have a BMI of 25 or higher, *2, *3 and it has also been reported that the hormone ghrelin, which stimulates appetite, increases by approximately 15% when sleep-deprived. *4 Sleep deprivation can lead to obesity, and obesity can, in turn, lower sleep quality, creating a vicious cycle. To address these issues, "Supplement GABA Thermo" and "Supplement GABA Diet" were developed as products that support users according to their specific concerns. *1 Grosicki GJ, et al. (2020). https://doi.org/10.1016/j.sleep.2020.04.013*2 BMI is an internationally used index to represent body mass, calculated as [weight (kg)] ÷ [height (m) squared].*3 Esmaeili N, et al. (2025). https://doi.org/10.1016/j.eclinm.2025.103221*4 Taheri S, et al. (2004). https://doi.org/10.1371/journal.pmed.0010062 "BrainSleep Supplement GABA" Series Product Features (Common to Series Products) The "BrainSleep Supplement GABA," which forms the base of the series products being launched, fundamentally improves sleep quality by simultaneously approaching both the brain and the gut. This time, in addition to these functions, we are expanding the series with products specialized for two specific concerns.1. GABA supports improved sleep quality and stress reductionContains 100mg of GABA, a functional ingredient that helps improve sleep quality, promote deep sleep and refreshing awakening, and reduce temporary mental stress and fatigue from work or study. It has been reported that taking GABA increases deep sleep time and improves mood upon waking within 7 days. *5*5 Food Sci. Biotechnol., 2016, 25(2), 547-551. Partially modified citation2. Lactic Acid Bacteria K-1 targets the gut, regulating digestive healthUnlike animal lactic acid bacteria that grow in nutrient-rich milk, Lactic Acid Bacteria K-1 are plant-based lactic acid bacteria that have survived harsh environments with low nutrients, low temperatures, and high acidity and salinity, and are therefore expected to have a powerful effect in the gut.3. Easy to continue with just 1 tablet a dayYou can get the equivalent of GABA from about 30 mini tomatoes and lactic acid bacteria from about 50 yogurts in just one tablet, making it easy to continue. Furthermore, it is manufactured in a GMP-certified factory in Toyama, ensuring safe consumption. "BrainSleep Supplement GABA" Series Lineup [New Product ①] Sleep care for those concerned about cold hands and feet or swelling"BrainSleep Supplement GABA + Thermo" Product Features ① Piperine derivatives from Long Pepper improve blood circulationLong pepper is a type of pepper plant native to South Asia, used as a crude drug in Ayurveda, a traditional Indian medicine, and in Chinese herbal medicine. The piperine derivatives contained in this plant, which has been passed down through a long history, are expected to strongly support the body's circulation from within, improving blood flow and reducing the decrease in body temperature. *6 Furthermore, by improving blood flow, it also supports the reduction of swelling. *7*6 Reduction of skin temperature in the extremities (hands and feet) due to cold*7 Swelling of the feet in healthy women (non-pathological transient evening swelling)② Cold hands relieved in 10 minutesPiperine derivatives from long pepper act on capillaries, relaxing blood vessel constriction and promoting blood circulation, thereby improving blood flow to the extremities. As a result, cold hands and feet are relieved, and body temperature balance is regulated. In fact, a study using piperine derivatives from long pepper confirmed a reduction in coldness with temperature changes 10 minutes after intake.③ Swelling improved in 6 hoursWhen blood vessel constriction is relaxed and blood circulation is promoted, it not only relieves coldness but also leads to an improvement in swelling. In fact, a study using piperine derivatives from long pepper confirmed that leg swelling was suppressed 6 hours after intake. [New Product ②] Supports prevention of snoring due to obesity"BrainSleep Supplement GABA + Diet" Product Features ① Ellagic acid extracted from pomegranate works to "inhibit fat formation" and "control sugar"Ellagic acid, found in pomegranates which have been used by people who value health and beauty for over 5000 years, is a natural polyphenol ingredient. Ellagic acid multi-dimensionally blocks fat accumulation by inhibiting the formation and enlargement of fat cells and by suppressing the storage of ingested sugars in fat cells.② In 12 weeks, weight, body fat, blood neutral fat, and waist circumference decreased, and elevated BMI improvedWeight gain is caused by a decrease in basal metabolism and the accumulation of fat. The functional ingredient ellagic acid acts on fat metabolism and supports a reduction in weight and body fat. Furthermore, by improving metabolic function, it also helps maintain a healthy body shape. In fact, a study conducted on obese individuals showed that 12 weeks of ellagic acid intake led to a decrease in weight, body fat, blood neutral fat, and waist circumference, and an improvement in elevated BMI. "BrainSleep Supplement GABA + Thermo" and "BrainSleep Supplement GABA + Diet" Product Details *This product has been notified to the Commissioner of the Consumer Affairs Agency as a product for which specific health purposes can be expected under the responsibility of the business operator.However, unlike Food for Specified Health Uses, it has not undergone individual review by the Commissioner of the Consumer Affairs Agency.*This product is not intended for the diagnosis, treatment, or prevention of disease.*Maintain a balanced diet, with staple foods, main dishes, and side dishes as a basis.
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