BRAIN SLEEP Co., Ltd. (Headquarters: Chiyoda-ku, Tokyo; Representative Director: Atsushi Hirota; hereinafter "BRAIN SLEEP") will begin selling "BRAIN SLEEP Supplement GABA" (hereinafter "Supplement GABA"), a multi-functional sleep supplement that improves sleep quality and contains two ingredients in one tablet, obtaining three functional claims, on the BRAIN SLEEP Official Website from May 1 (Thursday). "Supplement GABA" focuses on the gut-brain axis, a mechanism where the brain and gut mutually influence each other, which has been drawing attention in recent years. It contains two ingredients that are effective for caring for both the brain and gut: GABA, which and , and lactic acid bacteria K-1, which . By consciously caring for "both" the gut and brain, it supports sleep and mental and physical well-being. Development Background Focusing on the concept of "gut-brain axis" (where the brain and gut influence each other), which has been attracting attention in the latest medical research, it has been revealed that a healthy gut environment improves sleep quality. For example, in communication from the brain to the gut, stress can change gut function, leading to constipation or diarrhea. In communication from the gut to the brain, changes in the gut environment can cause anxiety or relaxation. There are also many effects related to sleep; by regulating the gut environment, the synthesis of serotonin, a precursor to the sleep hormone melatonin, is promoted, and the sleep rhythm is regulated. In recent years, "sleep quality" has also been attracting attention, and Japan, in particular, has the shortest average sleep time among OECD member countries, with daytime sleepiness and decreased performance becoming social issues. In the "Sleep Score Survey 2024" conducted by Brain Sleep targeting 10,000 employed individuals, approximately 20% responded that they "strongly feel that sleep affects productivity," and when combined with those who responded "it affects," the total reached approximately 70%. The same survey also found that in relation to "productivity and sleep quality" and "productivity and sleep duration," higher productivity levels tended to be associated with "higher sleep quality," but no correlation was observed with "sleep duration." This indicates that "sleep quality" may be superior in terms of productivity. Against this backdrop, we developed "Supplement GABA," which contains both GABA and plant-based lactic acid bacteria K-1, focusing on three elements: , , and . *1 Grosicki GJ, et al. (2020) https://doi.org/10.1016/j.sleep.2020.04.013 Sleep Score Survey Results Report 2024 (n=10,000)Productivity (rank): The results of the original survey questions were scored andthen converted into 4 ranks: A to D.(A: No issues, B: Minor issues, C: Issues, D: Needs improvement) Features of "BRAIN SLEEP Supplement GABA" 1. GABA Supports Improved Sleep Quality and Stress ReductionContains 100mg of GABA, a functional ingredient that helps improve sleep quality, including deeper sleep and refreshing awakenings, and reduce temporary mental stress and fatigue caused by work or study. It has been reported that taking GABA increases deep sleep time and improves mood upon waking in 7 days. *2 * 2 Food Sci. Biotechnol., 2016, 25(2), 547-551. Partially quoted with modifications [Test Method]10 healthy adult men and women (24-57 years old, 6 men, 4 women) who reported sleep quality issues were divided into two groups. They ingested capsules containing 100mg of GABA or no GABA for 7 days, followed by a 7-day washout period, and then the groups were switched and each ingested the respective capsules for another 7 days. 2.Lactic Acid Bacteria K-1 Approaches the Gut and Regulates Intestinal ConditionsContains plant-based lactic acid bacteria K-1 derived from rice, which is familiar to Japanese people.Unlike animal-based lactic acid bacteria that grow in nutrient-rich milk, plant-based lactic acid bacteria K-1 have strongly survived harsh environments with few nutrients, low temperatures, and high acidity and salinity. Therefore, they are said to have strong survival power in the intestines and are expected to work powerfully within the gut. 3. Easy to Continue with Just 1 Tablet a DayYou can easily supplement GABA equivalent to about 30 cherry tomatoes and lactic acid bacteria equivalent to about 50 yogurts with just one tablet, making it easy to continue. In addition, since it is manufactured at a GMP-certified factory in Toyama, you can take it with peace of mind. "BRAIN SLEEP Supplement GABA" Product Details Product Name: Brain Sleep Supplement GABA URL: https://brain-sleep.com/products/gaba Price (tax included): [Normal purchase price] 3,240 yen [Subscription price] First purchase 1,620 yen 2nd purchase onwards 2,592 yenContent: 13.5g (450mg x 30 tablets) Ingredients: Reduced maltose syrup (manufactured in Japan), GABA, vegetable lactic acid bacteria powder (vegetable lactic acid bacteria, dextrin)/cellulose, calcium carboxymethyl cellulose, calcium stearate, silicon dioxide microparticles, vitamin B₂Notification Label: This product contains GABA and vegetable lactic acid bacteria K-1 (L.casei327). It has been reported that GABA helps improve sleep quality (depth of sleep and refreshing awakening). It has also been reported to reduce temporary physical and mental stress and fatigue caused by work or study. Vegetable lactic acid bacteria K-1 (L.casei327) has been reported to help regulate bowel movements and improve defecation. [Consumer Affairs Agency Notification Information Notification Number: J462]*Maintain a balanced diet, primarily consisting of staple foods, main dishes, and side dishes.*This product has been registered with the Commissioner of the Consumer Affairs Agency as indicating that it can be expected to have specific health benefits under the responsibility of the business operator. However, it has not undergone individual review by the Commissioner of the Consumer Affairs Agency, unlike Food for Specified Health Uses.*This product is not intended for the diagnosis, treatment, or prevention of diseases.