Brain Sleep Inc. ( Headquarters: Chiyoda-ku, Tokyo, CEO: Atsushi Hirota, hereinafter referred to as "Brain Sleep" ) conducted a joint study (hereinafter referred to as "this study" ) with the Stanford University Sleep Biorhythm Laboratory (SCNL) to verify the effect on sleep of taking NMN ( nicotinamide mononucleotide), an ingredient that has attracted worldwide attention as a substance with the potential to slow aging and extend healthy lifespan. Previous studies on elderly people aged 65 and over have reported that taking NMN reduces daytime sleepiness and recovers fatigue, and research into its usefulness on sleep is also progressing. This study suggested that taking NMN may improve the quality of life (QOL ) of business people in their 40s to 60s by improving daytime sleepiness and reducing stress. background In recent years, as the importance of "maintaining youthful energy" to live a healthy and independent life has been emphasized, NMN has attracted the attention of researchers around the world. NMN is a type of vitamin B3 , and is produced in the body, but its production decreases with age. Previous research has reported that NMN activates the sirtuin gene, also known as an anti-aging gene, by converting it into NAD ( nicotinamide adenine dinucleotide), a nutrient necessary for metabolism and energy production in the body. Activating this sirtuin gene is expected to have the effect of regulating the aging process that occurs in the body. In addition, previous research on elderly people has reported that taking NMN reduces daytime sleepiness and recovers fatigue, and research is also progressing on its usefulness for sleep. * 1 In order to further verify the relationship between NMN and sleep, Brain Sleep has conducted a joint study with Stanford University on the effects of taking NMN on sleep in business people in their 40s to 60s . * 1 Kim, et al. (2022). ( https://pubmed.ncbi.nlm.nih.gov/35215405/ ) Research Summary Subjects: 30 healthy men and women in their 40s to 60s who had no history of taking NMN or niacin. Method: 15 people were randomly assigned to either an " NMN intake group" or a "placebo drug intake group" for 12 weeks. A comparison between the two groups was performed ( see study flow diagram ). Measurement items: Epworth Sleepiness Scale (ESS) * 2 , Short-Term Occupational Stress Assessment ( Stress Check ) * 3 , Pittsburgh Sleep Quality Index (PSQI) * 4 * 2 A questionnaire that is widely used to assess daytime sleepiness through self-reporting and to evaluate sleep disorders * 3 A self-administered stress questionnaire that can be easily used in the workplace * 4 A questionnaire widely used to evaluate sleep disorders <Research flow> Test Results Taking NMN has been shown to effectively improve sleep. Compared with the placebo group, ① Daytime sleepiness tends to improve from the 8th week of intake ② Stress tends to decrease from the 12th week of intake Result ①: Daytime sleepiness tended to improve in the NMN intake group from the 8th week of intake compared to the placebo group. The results of the ESS confirmed that the NMN intake group showed a tendency for daytime sleepiness to improve from the 8th week compared to the placebo group. Result 2: Stress levels in the NMN group tended to improve from the 12th week of intake compared to the placebo group. The results of the stress check confirmed that stress levels in the NMN intake group tended to improve from the 12th week compared to the placebo group. This study suggested that NMN intake may improve quality of life (QOL ) , such as improving daytime sleepiness and reducing stress, in subjective sleep-related evaluations. As the results were similar to those of previous studies, this study is significant in demonstrating the efficacy of NMN for sleep. This study was also presented at the 48th Annual Meeting of the Japanese Society of Sleep Research in 2024 . Launch of "Brain Sleep Coffee for Day" containing NMN Brain Sleep will begin selling "Brain Sleep Coffee for Day," a stick-type powdered coffee containing NMN , on the Brain Sleep official website from 11:00 a.m. on Tuesday, September 3 , 2024. To support the performance of busy modern people at the office, on the go, or in between work, the product dissolves in hot or cold water and comes in a portable package. ・"Brain Sleep Coffee for Day" product details Product name: Brain Sleep Coffee for Day URL: https://brain-sleep.com/products/coffee_for_day_30p Sales price: 30 packets 7,560 yen ( tax included ) Contents: 81.9g (2.73g x 30 packets ) Ingredients: Instant coffee ( made in Vietnam ) , GABA , β- nicotinamide mononucleotide (NMN) , lactic acid bacteria ( sterilized ) , dextrin ( contains some milk ingredients ) Comment from Seiji Nishino, Chief Research Advisor of Brain Sleep Ingestion of NMN , a precursor of NAD (nicotinamide adenine dinucleotide), acts as a coenzyme for dehydrogenase in the body, promoting metabolism and carrying out various physiological functions, so the health-maintaining effects of NMN intake have attracted attention. As we age, the production of NAD and NMN decreases, and NMN intake also activates the sirtuin gene, an anti-aging gene, so its anti-aging effects have been attracting attention in recent years. The results of this study showed that NMN intake is useful not only for elderly people but also for reducing daytime sleepiness and stress, which have a significant impact on work efficiency in working-age business people. Whether these effects are related to the activation of the sirtuin gene remains a future issue, but since NAD deficiency and disturbances in NAD homeostasis in the body can cause not only aging but also various diseases and pathologies, NMN intake is expected to be a supplemental therapy for maintaining health, which is currently desired in society. Seiji Nishino Professor of Psychiatry at Stanford University School of Medicine, Director of the Sleep Biorhythm Research Institute at Stanford University Founder and Chief Research Advisor of Brain Sleep Co., Ltd. Certified Medical Doctor, Designated Mental Health Physician, Specialist in the Japanese Society of Sleep Research, Industrial Physician
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