Brain Sleep Co., Ltd. (Headquarters: Chiyoda-ku, Tokyo; Representative Director: Atsushi Hirota; hereinafter referred to as "Brain Sleep") announced the results of a joint research and analysis based on a survey conducted with Seiji Nishino, Brain Sleep's Chief Research Advisor and Director of the Stanford University Sleep Biorhythm Laboratory (SCNL), at the 48th Annual Meeting of the Japanese Society of Sleep Research (hereinafter referred to as "this Society") held at Pacifico Yokohama North (Kanagawa Prefecture) from Thursday, July 18 to Friday, July 19, 2024. In this presentation, four presentations and a symposium were held, including an analysis of the relationship between NMN and sleep, and the actual state of children's sleep, "Sleep Standard Deviation KIDS," which Brain Sleep conducted its own survey. Brain Sleep also exhibited its first booth at this Society. Reference: 2021 "Sleep Standard Deviation KIDS" Survey Results Announced https://brain-sleep.com/service/sleepdeviationvalue/research2021kids/ Summary of presentation We have announced the results of a study and analysis conducted in collaboration with the Stanford University Sleep and Biorhythm Laboratory (SCNL). The study and analysis are based on Brain Sleep's own research into the actual state of children's sleep. Joint Research 1 Effects of Nicotinamide Mononucleotide (NMN) on Sleep In recent years, it has become clear that a decrease in intracellular nicotinamide adenine dinucleotide (NAD+) concentration causes aging-related disorders, and administration of nicotinamide mononucleotide (NMN) has attracted attention as it amplifies intracellular NAD+ and alleviates aging events (M. Igarashi et al., 2022). In relation to aging events, several papers have reported that NMN contributes to improving sleep quality, but these reports only evaluate subjective sleep quality, and there are few reports that obtain objective sleep data. Therefore, in this study, we conducted a 14-week clinical study on 30 subjects with the aim of clarifying the effects of NMN intake on sleep by adding objective indicators. Research and Analysis ① Inappropriate parental sleep habits lead to children's lack of sleep It is clear that lack of sleep in children has a negative impact on their health and growth, but it is not yet clear what the actual factors that cause sleep deprivation are, or what measures can be taken to improve the problem, so we analyzed the relationship between parents' sleep concepts and their children's sleep time.The results showed that when parents underestimate the amount of sleep their children need, their children's sleep time is reduced, and in order to ensure that children get enough sleep, it is also important to educate parents about the "amount of sleep necessary for children's health and development." Research and Analysis 2 Sleep and sleep hygiene as risk factors for children's behavior problems Sleep affects children's emotional and behavioral problems, but it is not clear which specific sleep factors have a strong influence. Therefore, we conducted an analysis to examine the influence of each sleep element on children's emotional and behavioral problems, and the influence of sleep hygiene, etc. on those sleep elements. As a result, we found that problems with each sleep element (sleep duration, mid-sleep awakening, mid-sleep time, CSHQ) each have a negative impact on children's emotions and behavior. It can also be said that providing children with an appropriate sleep environment can improve their sleep and further improve their difficulties. Research and Analysis ③ The relationship between nighttime sleep and its strength and difficulty, focusing on children's nap times It has been pointed out that if a child's nap is too long, it can delay bedtime and reduce sleep time. However, there are many unknowns about the effects of naps and nighttime sleep on children's mind and body, so we analyzed the effects of naps and nighttime sleep on children's emotions and behavioral problems. As a result, it was revealed that naps that are too long reduce nighttime sleep time and affect children's strengths and difficulties. Exhibition Booth We set up an exhibition booth for the first time at this conference, where we introduced examples of research, verification, and sleep consulting we have conducted with other companies and organizations. <Example of consulting business> - Examining the effect of reading before bed on sleep https://prtimes.jp/main/html/rd/p/000000165.000046684.html - Verification of a "house for good sleep" that combines hardware and software https://prtimes.jp/main/html/rd/p/000000171.000046684.html ・Joint research on "SAS risk assessment using AI image diagnosis" https://prtimes.jp/main/html/rd/p/000000172.000046684.html Symposium We held a symposium chaired by Seiji Nishino, Chief Research Advisor of Brain Sleep and Director of the Stanford University Sleep Biorhythm Laboratory (SCNL). Title: "Improving the well-being of shift workers (2nd session)" Chairs: Seiji Nishino / Stanford University, USA, Masanori Nishida / Waseda University The NOB Shift Work Study Group was launched in 2022 and has continued to invite members from academia and industry to discuss the health issues caused by shift work from various perspectives. Based on the lectures of each professor, this symposium summarized the current understanding of the well-being of shift workers from various perspectives and discussed what kind of social implementation is possible in the future.・ Molecular and neural mechanisms of circadian rhythm abnormalities caused by shift work (Hitoshi Okamura / Kyoto University, Yoshiaki Yamaguchi / Kansai University)・ Considering the well-being of shift workers from the perspective of the characteristics of human circadian rhythms and sleep-wake rhythms (Yujiro Yamanaka / Hokkaido University)・ Well-being and chrononutrition of shift workers (Narumi Nagai / University of Hyogo) ・ Relationship between individual differences in pathology and circadian rhythm characteristics in a shift work model (Kazuhiro Yagita / Kyoto Prefectural University of Dentistry)・Current situation, issues and solutions regarding shift work in the Japanese steel industry (Kensuke Kitani/ Shimabun Corporation)・ [Designated speech] Efforts to address health issues among shift workers (Masahiro Nakajima / Brain Sleep Co., Ltd.) Summary of the 48th Annual Meeting of the Japanese Society of Sleep Research Date: July 18, 2024 (Thursday) - July 19, 2024 (Friday) Venue: Pacifico Yokohama North Theme: "Dissection of Sleep Science - Broader, Deeper, and Further Ahead" Official website: https://www.c-linkage.co.jp/jssr48/index.html Chairman: Shintaro Chiba Ohta Sleep Science Center, Memorial Institute, Ohta General Hospital, Aijinkai Medical Corporation Department of Otolaryngology, The Jikei University School of Medicine
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